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Yes, prions is in the scrabble dictionary

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prions

noun

1. Plural form of prion.

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Here are some other words you could make with the letters prions, you can also
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Top Words by points

Points

Word Game

prison

8

Scrabble

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2 Letters

Scrabble® Points

in

2

pi

4

po

4

os

2

or

2

op

4

on

2

oi

2

si

2

no

2

is

2

so

2

3 Letters

Scrabble® Points

rip

5

rin

3

psi

5

pro

5

pos

5

poi

5

sin

3

sip

5

sir

3

son

3

sop

5

pis

5

pin

5

sri

3

nos

3

ors

3

ops

5

ons

3

ins

3

nor

3

nip

5

ion

3

4 Letters

Scrabble® Points

porn

6

pois

6

pros

6

inro

4

ions

4

iron

4

nips

6

rins

4

rips

6

pons

6

piso

6

pirn

6

pion

6

pins

6

noir

4

nori

4

snip

6

sori

4

sorn

4

spin

6

5 Letters

Scrabble® Points

prion

7

irons

5

inspo

7

rosin

5

ornis

5

porns

7

porin

7

pirns

7

pions

7

noirs

5

noris

5

opsin

7

orpin

7

6 Letters

Scrabble® Points

prison

8

prions

8

porins

8

orpins

8

spinor

8

Found 72 words in 0.21343 seconds