despite

1. Contemptuous defiance or disregard.

2. Spite; malice: "He died soon after . . . of pure despite and vexation” ( Sir Walter Scott).

3. The feeling or attitude of someone or something .

4. An act showing or .

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1. In spite of; notwithstanding: won the game despite overwhelming odds.

2. In of .

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1. To treat with .

2. To to anger .

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Here are some other words you could make with the letters despite, you can also
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Top Words by points	Points	Word Game
despite	10	Scrabble

2 Letters	Scrabble® Points
de	3
ed	3
es	2
et	2
id	3
is	2
it	2
pe	4
pi	4
si	2
te	2
ti	2

3 Letters	Scrabble® Points
dee	4
dep	6
die	4
dip	6
dis	4
dit	4
eds	4
est	3
ids	4
its	3
ped	6
pee	5
pes	5
pet	5
pie	5
pis	5
pit	5
psi	5
pst	5
see	3
sei	3
set	3
sip	5
sit	3
ted	4
tee	3
tes	3
tie	3
tip	5
tis	3

4 Letters	Scrabble® Points
deep	7
dees	5
deet	5
deps	7
desi	5
dies	5
diet	5
dips	7
dipt	7
dite	5
dits	5
edit	5
eide	5
ides	5
peds	7
pees	6
pest	6
pets	6
pied	7
pies	6
pits	6
seed	5
seep	6
sept	6
side	5
sipe	6
site	4
sped	7
spit	6
step	6
teds	5
teed	5
tees	4
tide	5
tied	5
ties	4
tips	6
peed	7

5 Letters	Scrabble® Points
deeps	8
deets	6
deist	6
diets	6
dites	6
edits	6
pedes	8
peise	7
piste	7
siped	8
sited	6
speed	8
spied	8
spite	7
steed	6
steep	7
stied	6
stipe	7
tepid	8
tides	6

6 Letters	Scrabble® Points
espied	9
peised	9
spited	9
stiped	9

7 Letters	Scrabble® Points
despite	10