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Yes, slough is in the scrabble dictionary

...and is worth 12 points by itself.

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slough

geographical name

1. Town England in Berkshire 98,600.

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noun

1. A depression or hollow, usually filled with deep mud or mire.

2. A stagnant swamp, marsh, bog, or pond, especially as part of a bayou, inlet, or backwater.

3. A state of deep despair or moral degradation.

4. An outer layer or covering that is shed.

5. Medicine A layer or mass of dead tissue separated from surrounding living tissue, as in a wound, sore, or inflammation.

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verb

1. To dispose of (a losing card in bridge) by discarding.

2. To get rid of or discard as irksome, objectionable, or disadvantageous .

3. To cast off.

4. To crumble slowly and fall away.

5. To separate in the form of dead tissue from living tissue.

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verb-intransitive

1. Medicine To separate from surrounding living tissue. Used of dead tissue.

2. To shed a slough.

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verb-transitive

1. To discard as undesirable or unfavorable; get rid of: slough off former associates.

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Here are some other words you could make with the letters slough, you can also
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Top Words by points

Points

Word Game

loughs

10

Scrabble

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2 Letters

Scrabble® Points

so

2

sh

5

go

3

us

2

uh

5

os

2

ho

5

oh

5

lo

2

3 Letters

Scrabble® Points

sho

6

ohs

6

soh

6

sol

3

sou

3

lug

4

log

4

hug

7

hog

7

ugh

7

gul

4

gos

4

4 Letters

Scrabble® Points

slog

5

shul

7

shog

8

slug

5

soul

4

sugh

8

ughs

8

lush

7

lugs

5

logs

5

hugs

8

hols

7

hogs

8

gush

8

guls

5

gosh

8

5 Letters

Scrabble® Points

lough

9

sough

9

ghoul

9

6 Letters

Scrabble® Points

loughs

10

ghouls

10

slough

10

Found 43 words in 0.18141 seconds