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Yes, trephine is in the scrabble dictionary

...and is worth 14 points by itself.

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trephine

noun

1. A surgical instrument having circular, sawlike edges, used to cut out disks of bone, usually from the skull.

2. A surgical instrument for cutting out circular sections (as of bone or corneal tissue).

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verb-transitive

1. To operate on with a trephine.

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Here are some other words you could make with the letters trephine, you can also
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Top Words by points

Points

Word Game

nephrite

13

Scrabble

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2 Letters

Scrabble® Points

eh

5

en

2

er

2

et

2

he

5

hi

5

in

2

it

2

ne

2

pe

4

pi

4

re

2

te

2

ti

2

3 Letters

Scrabble® Points

ere

3

ern

3

eth

6

hen

6

hep

8

her

6

het

6

hie

6

hin

6

hip

8

hit

6

ire

3

nee

3

net

3

nip

5

nit

3

nth

6

pee

5

peh

8

pen

5

per

5

pet

5

phi

8

pht

8

pie

5

pin

5

pit

5

ree

3

rei

3

rep

5

ret

3

rin

3

rip

5

tee

3

ten

3

the

6

tie

3

tin

3

tip

5

4 Letters

Scrabble® Points

erne

4

heir

7

hent

7

here

7

hern

7

hint

7

hire

7

neep

6

nite

4

peen

6

peer

6

pein

6

pent

6

pere

6

peri

6

pert

6

pier

6

pine

6

pint

6

pirn

6

pith

9

pree

6

rein

4

rent

4

rete

4

ripe

6

rite

4

teen

4

tein

4

tern

4

thee

7

then

7

thin

7

thir

7

tier

4

tine

4

tire

4

tree

4

trip

6

5 Letters

Scrabble® Points

enter

5

ether

8

hiree

8

inept

7

inert

5

inter

5

ither

8

niter

5

nitre

5

peter

7

preen

7

print

7

rente

5

repin

7

retie

5

ripen

7

terne

5

thein

8

their

8

there

8

thine

8

three

8

thrip

10

treen

5

trine

5

tripe

7

6 Letters

Scrabble® Points

either

9

entire

6

herein

9

hinter

9

inhere

9

nether

9

pterin

8

repent

8

repine

8

retine

6

theine

9

threep

11

triene

6

7 Letters

Scrabble® Points

inepter

9

neither

10

prithee

12

therein

10

8 Letters

Scrabble® Points

nephrite

13

trephine

13

Found 137 words in 0.30543 seconds