unsex

1. To deprive of sex or sexual power.

2. To deprive of the qualities typical of one's sex.

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1. To castrate.

2. To deprive of sexual capacity or sexual attributes.

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Here are some other words you could make with the letters unsex, you can also
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Top Words by points	Points	Word Game
nexus	12	Scrabble

2 Letters	Scrabble® Points
es	2
xu	9
us	2
un	2
nu	2
ne	2
ex	9
en	2

3 Letters	Scrabble® Points
nus	3
sen	3
sex	10
sue	3
sun	3
ens	3
uns	3
use	3

5 Letters	Scrabble® Points
nexus	12
unsex	12