Yes, uptake is in the scrabble dictionary

...and is worth 14 points by itself.

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Uptake Definition

noun

A passage for drawing up smoke or air.
from The American Heritage Dictionary of the English Language, 4th Edition
An act of taking in or absorbing, especially into a living organism.
from The American Heritage Dictionary of the English Language, 4th Edition
Understanding; comprehension: very quick on the uptake.
from The American Heritage Dictionary of the English Language, 4th Edition
A flue leading upward.
from Free Scrabble Dictionary
An act or instance of absorbing and incorporating especially into a living organism, tissue, or cell .
from Free Scrabble Dictionary

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Top Words by points

Points

takeup

12

2 letter words with UPTAKE

Points

at

2

pe

4

pa

4

ae

2

ta

2

te

2

ka

6

up

4

et

2

ut

2

3 letter words with UPTAKE

Points

tup

5

tea

3

tau

3

tap

5

tae

3

uke

7

put

5

uta

3

pea

5

pat

5

ute

3

pet

5

kat

7

ate

3

auk

7

eat

3

apt

5

ape

5

eau

3

eta

3

kae

7

kea

7

kep

9

kue

7

pak

9

4 letter words with UPTAKE

Points

puke

10

peat

6

peak

10

take

8

tape

6

teak

8

tepa

6

pate

6

kapu

10

kept

10

keta

8

5 letter words with UPTAKE

Points

kaput

11

taupe

7

6 letter words with UPTAKE

Points

takeup

12

uptake

12

Found 50 words in 0.18663 seconds