Scrabble Dictionary

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Yes, antithesis is playable

...and is worth 13 points.

Found in the following dictionaries

Enable (Words with friends)
SOWPODS (Collins Scrabble Words)
OTCWL2014 (NASPA Word List 2014)
TWL06 (NASPA List 2006)

"Antithesis" Definition

noun

A figure of speech in which sharply contrasting ideas are juxtaposed in a balanced or parallel phrase or grammatical structure, as in "Hee for God only, shee for God in him” ( John Milton).
Direct contrast; opposition.
The direct or exact opposite: Hope is the antithesis of despair.
The second and contrasting part of such a juxtaposition.
The second stage of the Hegelian dialectic process, representing the opposite of the thesis.

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