breakup

noun

1. The act of breaking up; disintegration or division.

   “Several factors led to speculation that the accident might have been caused by a bomb or missile strike, including heightened safety and security concerns because of the 1996 Olympics then being held in the United States, the fact that TWA flight 800 was an international flight, and the sudden and catastrophic nature of the in-flight breakup.”

2. The termination of a friendship or a romantic relationship.

   “"Eventually, I just pieced it together, figuring your butting heads could probably be explained by a break up. Years of anime shipping trained me for this."”

3. A loss of emotional control; a breakdown.
4. (Canada, Northern)The season during which winter ice covering bodies of water disintegrates; more generally, spring.