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Yes, lose is playable

...and is worth 5 points.

Found in the following dictionaries

Enable (Words with friends)
SOWPODS (Collins Scrabble Words)
OTCWL2014 (NASPA Word List 2014)
TWL06 (NASPA List 2006)

"Lose" Definition

idiom

Lose it Slang To become deranged or mentally disturbed.
Lose it Slang To become less capable or proficient; decline.
Lose it Slang To lose control; blow up.
Lose out on To miss (an opportunity, for example).
Lose time To delay advancement.

phrasal-verb

Lose out To fail to achieve or receive an expected gain.

verb-intransitive

To be defeated.
To operate or run slow. Used of a timepiece.
To suffer loss.

verb-transitive

To be deprived of (something one has had): lost her art collection in the fire; lost her job.
To be left alone or desolate because of the death of: lost his wife.
To be outdistanced by: chased the thieves but lost them.
To be unable to keep alive: a doctor who has lost very few patients.
To be unable to keep control or allegiance of: lost his temper at the meeting; is losing supporters by changing his mind.

verb

To bring to destruction.
To miss from one's possession or from a customary or supposed place.
To suffer deprivation of part with especially in an unforeseen or manner.
To suffer loss through the death or removal of or final separation from (a person).
To fail to keep control of or allegiance of.

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