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Yes, mesial is playable

...and is worth 10 points.

Found in the following dictionaries

Enable (Words with friends)
SOWPODS (Collins Scrabble Words)
OTCWL2014 (NASPA Word List 2014)
TWL06 (NASPA List 2006)

"Mesial" Definition

adjective

Dentistry Situated toward the middle of the front of the jaw along the curve of the dental arch.
Of, in, near, or toward the middle.
Of, relating to, or being the surface of a tooth that is next to the tooth in front of it or that is closest to the middle of the front of the jaw .

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