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Yes, poison is playable

...and is worth 10 points.

Found in the following dictionaries

Enable (Words with friends)
SOWPODS (Collins Scrabble Words)
OTCWL2014 (NASPA Word List 2014)
TWL06 (NASPA List 2006)

"Poison" Definition

noun

A substance that causes injury, illness, or death, especially by chemical means.
Chemistry & Physics A substance that inhibits another substance or a reaction: a catalyst poison.
Something destructive or fatal.
A substance that through its chemical action usually kills, injures, or impairs an organism.
Something destructive or harmful.

verb-transitive

Chemistry & Physics To inhibit (a substance or reaction).
To have a harmful influence on; corrupt: Jealousy poisoned their friendship.
To kill or harm with poison.
To pollute: Noxious fumes poison the air. See Synonyms at contaminate.
To put poison on or into: poisoning arrows; poisoned the drink.

adjective

Poisonous.
Impregnated with poison .

verb

To injure or kill with poison.
To treat, taint, or impregnate with or as if with poison.
To exert a baneful influence on .
To inhibit the activity, course, or occurrence of .
Administer poison to (a person or animal), either deliberately or accidentally.

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