Scrabble Dictionary

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Yes, pox is playable

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"Pox" Definition

noun

A disease such as chickenpox or smallpox, characterized by purulent skin eruptions that may leave pockmarks.
Archaic Misfortune and calamity.
Syphilis.
A virus disease (as chicken pox) characterized by pustules or eruptions.
A disastrous evil .

verb

To infect with a pox and especially with syphilis.