Scrabble Dictionary

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Yes, prohibition is playable

...and is worth 20 points.

Found in the following dictionaries

Enable (Words with friends)
SOWPODS (Collins Scrabble Words)
OTCWL2014 (NASPA Word List 2014)
TWL06 (NASPA List 2006)

"Prohibition" Definition

noun

A law, order, or decree that forbids something.
The act of prohibiting or the condition of being prohibited.
The forbidding by law of the manufacture, transportation, sale, and possession of alcoholic beverages.
The period (1920-1933) during which the 18th Amendment forbidding the manufacture and sale of alcoholic beverages was in force in the United States.
The act of by authority.

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