Scrabble Dictionary

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Yes, synizesis is playable

...and is worth 21 points.

Found in the following dictionaries

Enable (Words with friends)
SOWPODS (Collins Scrabble Words)
OTCWL2014 (NASPA Word List 2014)
TWL06 (NASPA List 2006)

"Synizesis" Definition

noun

Biology The phase of meiosis in some species in which the chromatin contracts into a mass at one side of the nucleus.

Source: American Heritage Dictionary

Linguistics The union in pronunciation of two adjacent vowels into one syllable without forming a diphthong.

Source: American Heritage Dictionary

Contraction of two syllables into one by uniting in pronunciation two adjacent vowels.

Source: Merriam-Webster

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