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Yes, tonicity is playable

...and is worth 14 points.

Found in the following dictionaries

Enable (Words with friends)
SOWPODS (Collins Scrabble Words)
OTCWL2014 (NASPA Word List 2014)
TWL06 (NASPA List 2006)

"Tonicity" Definition

noun

Normal firmness or functional readiness in body tissues or organs.
The sustained partial contraction of resting or relaxed muscles.
The property of possessing tone.
Healthy vigor of body or mind.
Muscular tonus.

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