irreversible

adj

1. (not-comparable)Incapable of being reversed or turned about or back; incapable of being made to run backwards.

   “an irreversible engine”

2. (not-comparable)Incapable of being reversed, recalled, repealed, or annulled.

   “an irreversible sentence or decree”

   “Manganism has been known about since the 19th century, when miners exposed to ores containing manganese[…]began to totter, slur their speech and behave like someone inebriated. The poisoning was irreversible, and soon ended in psychosis and death.”

   ““Even under a variety of policies, including plastic product reduction, waste management, and environmental recycling, microplastic pollution is irreversible and escalating.””

3. (not-comparable)Incapable of being reversed to the original state without consumption of free energy and increase of entropy.