irritation

noun

1. (countable, uncountable)The act of irritating or annoying.

   “What irritation causes you to be so moody?”

2. (countable, uncountable)The state of being irritated.

   “It has already been established that the crew was competent and qualified for operation of AS66. With the exception of some overtones of irritation about the manner in which another aircraft, N799Y, affected the flight's progress into the Juneau area, the recorded cockpit conversation, in general, reflects a relaxed but businesslike atmosphere.”

   “Last spring, the periodical cicadas emerged across eastern North America. Their vast numbers and short above-ground life spans inspired awe and irritation in humans—and made for good meals for birds and small mammals.”

   “CNN spoke recently with several Conyers residents who said they still have blurry vision, shortness of breath, throat irritation or chronic headaches since the chemical plant fire.”

3. (countable, uncountable)A thing or person that annoys.
4. (countable, uncountable)A state of inflammation or of painful reaction to cell or tissue damage.
5. (countable, uncountable)A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.

   “Hip pain is a common complaint in children and may indicate a very mild irritation in the hip joint or may be the symptom of a very severe abnormality”