malignancy

noun

1. (countable, uncountable)The state of being malignant or diseased.
2. (countable, uncountable)A malignant cancer; specifically, any neoplasm that is invasive or otherwise not benign.
3. (countable, uncountable)That which is malign; evil, depravity, malevolence.

   “[T]he malignancie of my fate, might perhaps diſtemper yours; […]”

   “A cold wind swept down from it and set us shivering. Somewhere there, on that desolate plain, was lurking this fiendish man, hiding in a burrow like a wild beast, his heart full of malignancy against the whole race which had cast him out.”

   “Because of the dearth of recent feminist writing about conditions in mental institutions, it's possible for us to image that they must have improved since the mid-'70s. Millett reminds us forcefully of the hellishness and malignancy of these places, where mind-altering drugs are prescribed punitively or at random, attendants are abusive, food is unhealthy, and numbing boredom, ugliness, pain and filth prevail.”