Scrabble Dictionary

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Yes, opioid is playable

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TWL06 (NASPA List 2006)

"Opioid" Definition

noun

See opiate.
A synthetic drug possessing narcotic properties similar to opiates but not derived from opium.
Any of a group of endogenous neural polypeptides (as an endorphin or enkephalin) that bind especially to opiate receptors and mimic some of the pharmacological properties of opiates .

adjective

Of, involving, or induced by an opioid.
Possessing some properties characteristic of opiate narcotics but not derived from opium.