psychosis

noun

1. (countable, uncountable)A severe mental disorder, sometimes with physical damage to the brain, marked by a deranged personality and a distorted view of reality.

   “Manganism has been known about since the 19th century, when miners exposed to ores containing manganese[…]began to totter, slur their speech and behave like someone inebriated. The poisoning was irreversible, and soon ended in psychosis and death.”