Scrabble Dictionary

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Yes, downer is playable

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TWL06 (NASPA List 2006)

"Downer" Definition

noun

Slang A depressant or sedative drug, such as a barbiturate or tranquilizer.
Slang One that depresses, such as an experience or person.
A weak, sick, or crippled animal in shipment that is down and cannot get up.
A depressant drug.
Someone or something depressing, disagreeable, or unsatisfactory.